Key result
Maternal indomethacin and paracetamol use linked to fetal ductus arteriosus constriction and RV dilation.
Why the study?
Premature constriction of the fetal ductus arteriosus causes fetal cardiac compromise and is triggered by maternal prostaglandin-inhibiting analgesics, prompting description of two temporally associated cases.
Case Report (n=2)
Maternal use of prostaglandin-inhibiting analgesics, including indomethacin and paracetamol, can trigger fetal ductus arteriosus constriction requiring targeted fetal echocardiography and potential early delivery.
No takes yet. Share an insight, caveat, or question.
Alerts clinicians to possible fetal ductal risks with prostaglandin inhibitors; leaves open causal inference from these case reports.
Çakır et al. (2026) conducted a case report in Fetal ductus arteriosus constriction (n=2). Maternal analgesic exposure (indomethacin, paracetamol) was evaluated on Fetal ductus arteriosus constriction. Maternal exposure to prostaglandin-inhibiting analgesics (indomethacin and paracetamol) was temporally associated with fetal ductus arteriosus constriction and right ventricular dilation in 2 cases.
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