Key result
Modifying the glucose minimal model to account for counterregulatory reflex responses improved predictions for glucose and NEFA kinetics during insulin-modified intravenous glucose tolerance tests.
Why the study?
Does a modified mathematical model accounting for counterregulatory response improve the prediction of glucose and NEFA kinetics during IM-IVGTT in healthy subjects?
Does a modified mathematical model accounting for counterregulatory response improve the prediction of glucose and NEFA kinetics during IM-IVGTT in healthy subjects?
Modifying the glucose minimal model to account for counterregulatory responses improves the estimation of insulin sensitivity and glucose/NEFA kinetics during IM-IVGTT.
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CRR must be modeled in IM-IVGTT analyses to avoid bias; leaves open whether adjusted models improve metabolic research accuracy.
Thomaseth et al. (2014) studied Healthy nondiabetic subjects (n=13). Modified insulin-modified intravenous glucose tolerance test (GC-IM-IVGTT) vs. Standard IM-IVGTT was evaluated on Model predictions of glucose and NEFA kinetics. Modifying the glucose minimal model to account for counterregulatory reflex responses improved predictions for glucose and NEFA kinetics during insulin-modified intravenous glucose tolerance tests.
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