Key result
Activation of platelets with ADP or thrombin leads to a time-dependent, GP IIb-IIIa-independent association between bound fibrinogen and the platelet cytoskeleton.
Population
Aspirin-treated, gel-filtered platelets (n=14 for ADP-treated)
Comparison
Activation with 20 µmol/L adenosine diphosphate… vs Resting platelets, or binding inhibited by RGDS…
Design
Preclinical
Follow-up
60 minutes
Authors
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May inform platelet activation models; leaves open relevance to human thrombosis or therapy.
GP IIb-IIIa-mediated fibrinogen binding to activated platelets is accompanied by time-dependent alterations leading to a GP IIb-IIIa independent association between bound fibrinogen and the platelet cytoskeleton.
EI Peerschke (1991) studied this question. Adenosine diphosphate (ADP) or human thrombin (THR) vs. Resting platelets was evaluated on Percentage of membrane-bound 125I-fibrinogen in the cytoskeleton. Activation of platelets with ADP or thrombin leads to a time-dependent, GP IIb-IIIa-independent association between bound fibrinogen and the platelet cytoskeleton.
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