Key result
Point-of-care INR analyzers showed very good agreement with laboratory methods, with >90% of CoaguChek XS and i-STAT 1 results falling within 0.4 INR units of the reference.
Why the study?
Does capillary whole blood INR measurement using point-of-care analyzers accurately reflect venous plasma INR determined by a reference laboratory method?
Observational
Does capillary whole blood INR measurement using point-of-care analyzers accurately reflect venous plasma INR determined by a reference laboratory method?
Point-of-care INR analyzers (CoaguChek XS and i-STAT 1) demonstrate high accuracy compared to reference laboratory methods, supporting their use in clinical practice with ongoing quality assurance.
We evaluated the accuracy of capillary whole blood international normalized ratio (INR) on the CoaguChek S (Roche Diagnostics, Indianapolis, IN), CoaguChek XS (Roche Diagnostics), and i-STAT 1 (i-STAT, East Windsor, NJ) point-of-care (POC) analyzers compared with venous plasma INRs determined by a reference laboratory method. Overall agreement between POC and laboratory plasma INR was very good, with median bias between capillary whole blood and laboratory plasma INRs varying from 0.0 to -0.2 INR units on all devices. More than 90% of results on the CoaguChek XS and i-STAT 1 and 88% of CoaguChek S results were within 0.4 INR units of the reference laboratory method. The CoaguChek XS and i-STAT 1 demonstrated greater accuracy than the CoaguChek S as measured by the number of results that differed by more than 0.5 INR units from the reference method. Median bias between CoaguChek S capillary whole blood and laboratory plasma INRs changed over time, demonstrating the need for ongoing quality assurance measures for POC INR programs.
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Karon et al. (2008) reported an observational. Capillary whole blood INR on CoaguChek S, CoaguChek XS, and i-STAT 1 point-of-care analyzers vs. Venous plasma INRs determined by a reference laboratory method was evaluated on Agreement between point-of-care and laboratory plasma INR. Point-of-care INR analyzers showed very good agreement with laboratory methods, with >90% of CoaguChek XS and i-STAT 1 results falling within 0.4 INR units of the reference.
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