Why the study?
Does INR measurement using point-of-care devices (i-STAT PT/INR and CoaguChek XS Plus) provide accurate and clinically correlated results compared to laboratory-based venipuncture in patients receiving oral warfarin therapy?
Population
52 patients receiving oral warfarin therapy in an outpatient, pharmacist-managed anticoagulation clinic
Comparison
INR measurement using two point-of-care devices vs INR measurement by laboratory-based venipuncture
Design
Cross-sectional
Authors
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POC INR discrepancies may alter warfarin dosing decisions; leaves open reliability for routine use pending prospective validation.
Does INR measurement using point-of-care devices (i-STAT PT/INR and CoaguChek XS Plus) provide accurate and clinically correlated results compared to laboratory-based venipuncture in patients receiving oral warfarin therapy?
Point-of-care INR devices may exhibit positive bias compared to laboratory venipuncture, which can lead to different therapeutic decisions in up to 33-54% of cases.
Donaldson et al. (2010) studied this question.
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