Key result
Abrupt withdrawal of long-term propranolol in dogs did not cause heightened beta receptor sensitivity, and partial beta blockade remained present at 24 hours.
Why the study?
Does abrupt withdrawal of long-term propranolol cause heightened beta receptor sensitivity in conscious dogs?
Population
n=6 conscious dogs
Comparison
Abrupt withdrawal of long-term oral propranolol vs Premedication baseline values
Design
Preclinical
Follow-up
one week postmedication
Authors
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Challenges beta hypersensitivity hypothesis after propranolol withdrawal in dogs; leaves open alternative mechanisms and human relevance.
Does abrupt withdrawal of long-term propranolol cause heightened beta receptor sensitivity in conscious dogs?
Abrupt withdrawal of long-term propranolol in a canine model does not lead to heightened beta receptor sensitivity, suggesting other mechanisms may be responsible for adverse withdrawal reactions in patients with coronary disease.
Myers et al. (1978) studied this question. Abrupt withdrawal of propranolol vs. Premedication baseline was evaluated on Beta receptor reactivity to catecholamine stimulation (heart rate, dP/dt max, and plasma free fatty acids). Abrupt withdrawal of long-term propranolol in dogs did not cause heightened beta receptor sensitivity, and partial beta blockade remained present at 24 hours.
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