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Granuloma after liquid silicone augmentation of the upper eyelids was studied by light and electron microscopy and energy dispersive x-ray analysis. Light microscopy showed proliferation of collagen fibers and many phagocytic macrophages with vacuoles. Electron microscopy showed many vacuoles in phagocytic macrophages, fragmentary myofibrils, and proliferation of collagen fibers. Vacuoles in phagocytic macrophages contained silicone that was demonstrated by energy dispersive x-ray analysis. The present case suggests that liquid silicone injection in the eyelid can induce degeneration of the orbicularis oculi muscle in addition to granuloma formation.
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Amemiya et al. (1994) studied this question.
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