Key result
An in silico model based on oscillatory shear index demonstrated progressive stenosis with statistically significant increases in regions of high OSI (OSI > 0.2, p < 0.05) in 6 of 11 carotid arteries.
Why the study?
The study was designed to describe and demonstrate the applicability of a novel in silico method for modeling progressive carotid artery stenosis using the oscillatory shear index as the basis of stenosis function.
p-value: p=<0.05
This novel computational model demonstrates the feasibility of using oscillatory shear index to simulate progressive carotid artery stenosis.
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Supports OSI-based in silico modeling of carotid stenosis progression; hypothesis-generating and requires prospective in vivo validation before clinical use.
Peter Patalano (2022) studied Carotid artery stenosis (n=11). In silico stenosis modeling based on oscillatory shear index (OSI) vs. Baseline hemodynamics was evaluated on Progressive stenosis measured by increases in regions of high OSI (OSI > 0.2) (p=<0.05). An in silico model based on oscillatory shear index demonstrated progressive stenosis with statistically significant increases in regions of high OSI (OSI > 0.2, p < 0.05) in 6 of 11 carotid arteries.
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