Fattening up: Artificially constructed lipid–protein conjugates can be used to control protein activity and localization at either biological or artificial membrane interfaces. Here, we report a facile technique for the lipid modification of proteins catalyzed by microbial transglutaminase (MTG). MTG-mediated protein lipidation proceeded efficiently without perturbing protein functionality (see figure).
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Abe et al. (2011) studied this question.
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