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January 1, 1993Epilepsia

Calcium‐Dependent Regulation of Genetically Determined Spike and Waves by the Reticular Thalamic Nucleus of Rats

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Key result

Injection of Cd2+ into the reticular thalamic nucleus reversibly suppressed ipsilateral spike and wave discharges in GAERS rats, whereas injection into the ventrobasal complex only slightly reduced them.

Population

GAERS (genetic absence epilepsy rats from Strasbourg) strain rats

Comparison

Lesioning of the reticular thalamic nucleus by… vs Injection of Cd2+ into the ventrobasal complex

Design

Preclinical

Authors

GAG. AvanziniFondazione IRCCS Istituto Neurologico Carlo BestaMVMarguerite VergnesNovartis (Switzerland)RSRoberto SpreaficoFondazione IRCCS Istituto Neurologico Carlo Besta

Discussion

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Implication

Suggests reticular thalamic Ca2+ oscillations drive absence seizures in rats; leaves open translation to human therapies.

Structured PICO

P
Population
GAERS rats with generalized nonconvulsive epilepsy.
I
Intervention
Lesioning of the reticular thalamic nucleus (RT) by ibotenic acid, or injection of Cd2+ (0.5-1.5 microliter, 1 mM) into the RT
C
Comparator
Injection of Cd2+ into the ventrobasal (VB) complex
O
Outcome
Expression of ipsilateral spike and wave discharges (SWD)surrogate

Ca(2+)-dependent oscillatory properties of the reticular thalamic nucleus are critical for the expression of genetically determined spike and wave discharges in a rat model of absence epilepsy.

Cite This Study

Avanzini et al. (1993) studied Generalized nonconvulsive epilepsy. Injection of Cd2+ into the reticular thalamic nucleus vs. Injection of Cd2+ into the ventrobasal (VB) complex was evaluated on Ipsilateral spike and wave discharges (SWD). Injection of Cd2+ into the reticular thalamic nucleus reversibly suppressed ipsilateral spike and wave discharges in GAERS rats, whereas injection into the ventrobasal complex only slightly reduced them.

synapsesocial.com/papers/6a9e70e92bf3873a96f9bb80https://doi.org/10.1111/j.1528-1157.1993.tb02369.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intrinsic properties of nucleus reticularis thalami neurones of the rat studied in vitro.1989 · 231 citations
  2. 2Electrophysiology of neurons of lateral thalamic nuclei in cat: resting properties and burst discharges1984 · 450 citations
  3. 3Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice1999 · 3,623 citations
  4. 4Some aspects of the organization of the thalamic reticular complex1975 · 588 citations
  5. 5Characterization of ethosuximide reduction of low‐threshold calcium current in thalamic neurons1989 · 509 citations