Key result
Whole-genome sequencing of the ROK62 Sapovirus strain from South Korea identified it as genotype GI-1, sharing 94% nucleotide sequence identity with the Manchester and Mc114 strains.
This first whole-genome sequence analysis of Sapovirus in South Korea provides a reference for tracking epidemic spread and developing diagnostic methods.
First SaV whole-genome sequence from South Korea; leaves open its role in epidemic tracking and diagnostics.
Sapovirus (SaV), a virus residing in the intestines, is one of the important causes of gastroenteritis in human beings. Human SaV genomes are classified into various genogroups and genotypes. Whole-genome analysis and phylogenetic analysis of ROK62, the SaV isolated in South Korea, were carried out. The ROK62 genome of 7429 nucleotides contains 3 open-reading frames (ORF). The genotype of ROK62 is SaV GI-1, and 94% of its nucleotide sequence is identical with other SaVs, namely Manchester and Mc114. Recently, SaV infection has been on the rise throughout the world, particularly in countries neighboring South Korea; however, very few academic studies have been done nationally. As the first whole-genome sequence analysis of SaV in South Korea, this research will help provide reference for the detection of recombination, tracking of epidemic spread, and development of diagnosis methods for SaV.
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Choi et al. (2015) studied Sapovirus infection (n=1). Whole-genome sequencing was evaluated on Genomic characterization and phylogenetic classification. Whole-genome sequencing of the ROK62 Sapovirus strain from South Korea identified it as genotype GI-1, sharing 94% nucleotide sequence identity with the Manchester and Mc114 strains.
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