In vitro Activity of Linezolid in Staphylococcus aureus

In vitro Activity of Linezolid in Staphylococcus aureusDear Editor, Out of 100 S.aureus, 28 (28.0%) were ORSA and 80 (80%) were multiply resistant to more than 3 antimicrobials.Sensitivity of ORSA to tetracycline, erythromycin, cefazolin, amikacin and cefuroxime was quite low while 57.1% and 100% strains were sensitive to clindamycin and vancomycin respectively.By disc diffusion method 99% were linezolid sensitive.The MIC range for ORSA was 0.5-4mg/L with MIC 50 2mg/ L and MIC 90 2mg/L.The MIC range for OSSA was 1-2 mg/L with MIC 50 2mg/L and MIC 90 2mg/L.The single isolate resistant by disc diffusion was ORSA with MIC 4 mg/L.Overall sensitivity of S.aureus to Linezolid was 100% by agar dilution method.