In brief: Abnormal blood chemistry values may be a normal physiological response to marathon running and training. This was shown by elevations in creatine phosphokinase, high density lipoproteins, lactate dehydrogenase, and WBCs after a marathon run. Significant changes(p <.05) were noted in all blood parameters except globulin and high density lipoproteins from subjects before the race to immediately after the race and two to three weeks after the race. Insignificant differences in blood chemistry values were observed in runners with different running speeds, previous marathon experience, age, body weight, and average training miles per week.
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Krebs et al. (1983) studied this question.
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