Summary. The influence of an α and β blocking agent (phenoxybenzamine and propranolol) on the leucocyte response to adrenaline has been studied in three healthy male subjects. Blood pressure and pulse rate measurements established that effective α and β blockade of the cardiovascular effects of adrenaline was achieved. There appeared to be a biphasic cardiovascular effect within the first hour after adrenaline injection. Neither agent produced any marked alteration in the pattern of adrenaline‐induced leucocytosis, but when given in combination the subsequent white cell response to adrenaline was substantially diminished. Our findings do not substantiate the view that the leucocytosis provoked by adrenaline results from mobilization of intravascular marginated cells as a direct consequence of alterations in blood flow. The receptors involved appear to be equally sensitive to the α and the β properties of adrenaline, without discriminating between them.
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French et al. (1971) studied this question.
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