Development of a Recyclable Fluorous Chiral Phase-Transfer Catalyst: Application to the Catalytic Asymmetric Synthesis of α-Amino Acids

[structure: see text] A recyclable fluorous chiral phase-transfer catalyst was synthesized and successfully applied for the catalytic asymmetric synthesis of both natural and unnatural alpha-amino acids. The reaction involves alkylation of a glycine derivative followed by extractive recovery of the chiral phase-transfer catalyst using fluorous solvent.