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A previous report demonstrated that intrapulpal application of an antibiotic/corticosteroid combination effectively eliminates experimentally induced external inflammatory resorption in monkey teeth. The aim of this study was to examine the direct effects of this medicament on dentinoclasts cultured in vitro. Isolated dentinoclasts were cultured in the presence of either the endodontic paste or antibiotics. Results showed that the steroid component of the paste directly inhibited the spreading of dentinoclasts, suggesting that this medicament acts by detaching resorbing dentinoclasts from the root surface.
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Pierce et al. (1988) studied this question.
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