Key result
Experimental infection with feline infectious peritonitis virus enhanced platelet reactivity to ADP and epinephrine in specific-pathogen-free cats compared to baseline.
Population
6 specific-pathogen-free cats
Comparison
Intraperitoneal inoculation with feline… vs Baseline (prior to inoculation)
Design
Preclinical
Follow-up
21 days
Authors
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Does not support clinical changes in humans; leaves open viral effects on platelet reactivity for translational cardiovascular research.
Experimental FIPV infection in cats enhances platelet reactivity to ADP and epinephrine, suggesting a potential viral effect on platelets or endothelial cells.
Boudreaux et al. (1990) studied Feline infectious peritonitis virus infection (n=6). Intraperitoneal inoculation with feline infectious peritonitis virus (FIPV) vs. Baseline (pre-inoculation) was evaluated on Platelet aggregation and 14C-serotonin release. Experimental infection with feline infectious peritonitis virus enhanced platelet reactivity to ADP and epinephrine in specific-pathogen-free cats compared to baseline.
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