Key result
Minimally invasive fetal procedures carry a maternal complication risk of about 5% (1% severe), while open fetal surgery carries important risks in the index and subsequent pregnancies.
Why the study?
What are the maternal risks associated with fetal therapy?
What are the maternal risks associated with fetal therapy?
This review highlights that while transplacental medical therapies are generally safe for mothers, minimally invasive and open fetal surgeries carry quantifiable maternal risks that require careful counseling.
Supports maternal risk counseling in fetal surgery; leaves open need for prospective validation of techniques.
PURPOSE OF REVIEW: Although most fetal disorders can be treated after birth, a few conditions that predictably lead to fetal or neonatal death, or that progress significantly before birth, are ideally treated prenatally. The number of centers offering fetal therapeutic procedures is gradually increasing worldwide. Patients and caregivers should be aware of the potential maternal risks of these interventions. RECENT FINDINGS: For transplacental medical therapy (corticosteroids, antiarrhythmics and immunoglobulins), severe maternal adverse events are rare, when done in expert centers. Minimally invasive procedures carry a risk of maternal complications of about 5%, with 1% being severe complications (pulmonary edema or placental abruption). Open fetal surgery carries important risks to the mother, both in the index pregnancy (pulmonary edema, placental abruption, chorioamnionitis and scar dehiscence) and in subsequent pregnancies (uterine rupture), yet some of these risks are decreasing with surgical refinement and increasing experience of the surgical team. SUMMARY: The information in this manuscript provides a base to counsel expectant mothers on risk of fetal therapy.
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Alrefai et al. (2017) conducted a review in Fetal disorders requiring prenatal treatment. Fetal therapy (medical, minimally invasive, and open surgery) was evaluated on Maternal complications. Minimally invasive fetal procedures carry a maternal complication risk of about 5% (1% severe), while open fetal surgery carries important risks in the index and subsequent pregnancies.
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