The mechanism of the reaction of 2,3‐epoxypropyl phenyl ether (2), as a model compound, with 1‐cyanoguanidine (3), for which different pathways have been proposed, is investigated using HPLC and 1H NMR spectroscopy. The effect of stoichiometric ratio, temperature and catalytic reagent was studied. It was found that, independent on the stoichiometric ratio, at low temperature, etherification and addition at the primary amino group takes place and reaction of the cyano group only to a low extend. At higher temperature, HPLC diagrams show different peaks indicating a different mechanism.
No takes yet. Share an insight, caveat, or question.
Galy et al. (1987) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: