Key result
Viral infections alter host cell mRNA splicing, a complex interaction requiring advanced RNA sequencing and multi-omics integration for comprehensive analysis.
Why the study?
Alteration of host cell splicing during viral infections remains underappreciated due to the complexity and technical challenges of studying alternative splicing regulation.
Viral infections can significantly alter host cell alternative splicing, requiring advanced single-cell and multi-omics approaches to fully understand these complex virus-host interactions.
Viral splicing changes may affect infection outcomes; leaves open whether targeting AS offers antiviral strategies.
Alteration of host cell splicing is a common feature of many viral infections which is underappreciated because of the complexity and technical difficulty of studying alternative splicing (AS) regulation. Recent advances in RNA sequencing technologies revealed that up to several hundreds of host genes can show altered mRNA splicing upon viral infection. The observed changes in AS events can be either a direct consequence of viral manipulation of the host splicing machinery or result indirectly from the virus-induced innate immune response or cellular damage. Analysis at a higher resolution with single-cell RNAseq, and at a higher scale with the integration of multiple omics data sets in a systems biology perspective, will be needed to further comprehend this complex facet of virus-host interactions.
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Ashraf et al. (2018) conducted a review in Viral infections. Viral infection was evaluated on Alteration of host cell splicing. Viral infections alter host cell mRNA splicing, a complex interaction requiring advanced RNA sequencing and multi-omics integration for comprehensive analysis.
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