Key result
Depression remission in patients with chronic heart failure was associated with significantly greater improvement in the 6-minute walk test compared to nonremission (63.51 vs 16.24 m; P=0.03).
Why the study?
Does sertraline improve health status in patients with chronic heart failure and major depressive disorder?
Population
469 participants with chronic heart failure and major depressive disorder based on Diagnostic Statistics…
Comparison
Sertraline for 12 weeks vs Placebo for 12 weeks
Design
RCT, randomized
Follow-up
12 weeks
Authors
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Remission of depression may enhance functional capacity in heart failure; extends evidence linking symptom remission to better patient-centered outcomes.
RCT (n=469)
Placebo-controlled
Randomized
Does sertraline improve health status in patients with chronic heart failure and major depressive disorder?
Absolute Event Rate: 63.51% vs 16.24%
p-value: p=0.03
In patients with chronic heart failure and major depressive disorder, remission of depressive symptoms is associated with significant improvements in physical function, social function, and quality of life.
Xiong et al. (2012) conducted an RCT in Chronic heart failure and major depressive disorder (n=469). Depression remission vs. Nonremission was evaluated on 6-minute walk test improvement (difference from baseline) (p=0.03). Depression remission in patients with chronic heart failure was associated with significantly greater improvement in the 6-minute walk test compared to nonremission (63.51 vs 16.24 m; P=0.03).
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