Key result
Among patients with acute myocardial infarction undergoing percutaneous coronary intervention, female sex was not associated with a higher risk of 1-year major adverse cardiac and cerebrovascular events compared to male sex after propensity score matching (HR 1.032).
Why the study?
Data regarding gender differences in outcomes after PCI are conflicting, and gender differences in clinical outcomes after PCI for AMI in Asian populations remain uncertain.
Does female gender affect 30-day and 1-year MACCE in Korean patients with acute myocardial infarction undergoing percutaneous coronary intervention compared to male gender?
Cohort (n=10,568)
Yes
Does female gender affect 30-day and 1-year MACCE in Korean patients with acute myocardial infarction undergoing percutaneous coronary intervention compared to male gender?
Hazard Ratio: 1.032 (95% CI 0.802–1.328)
Absolute Event Rate: 9.3% vs 9%
p-value: p=0.803
In a Korean AMI population undergoing PCI, women and men had similar 30-day and 1-year clinical outcomes and bleeding risks despite different baseline characteristics.
Observational data on sex differences in Asian AMI patients post-PCI remain inconclusive; leaves open whether sex-specific strategies warrant prospective validation.
BACKGROUND: There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention (PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction (AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. METHODS: = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events (MACCE) in women with those in men after AMI by using propensity score (PS) matching. RESULTS: = 0.215, HR = 1.255, 95% CI: 0.869-1.814). CONCLUSIONS: Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up.
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Lee et al. (2020) conducted a cohort in Acute myocardial infarction (n=10,568). Female sex vs. Male sex was evaluated on 1-year major adverse cardiac and cerebrovascular events (MACCE) (HR 1.032, 95% CI 0.802-1.328, p=0.803). Among patients with acute myocardial infarction undergoing percutaneous coronary intervention, female sex was not associated with a higher risk of 1-year major adverse cardiac and cerebrovascular events compared to male sex after propensity score matching (HR 1.032).
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