Photodynamic Therapy for Choroidal Nevus With Subfoveal Fluid

PURPOSE: To report the efficacy of photodynamic therapy (PDT) for management of choroidal nevus associated with subfoveal fluid. METHODS: A retrospective chart review of 15 patients with choroidal nevus and associated subfoveal fluid treated with PDT was performed. Standard-fluence PDT was used in all patients and response to treatment was assessed with optical coherence tomography. RESULTS: Complete resolution of subfoveal fluid was achieved in 9 eyes (60%) and partial resolution in 4 eyes (27%); 1 eye (7%) experienced worsening subfoveal fluid, and 1 eye (7%) was stable after PDT. After PDT, visual acuity improved in 8 eyes (53%), was stable in 6 (40%), and worsened in 1 eye (7%). Five patients (33%) required a second session of PDT with a median of 4 months (mean, 9 months; range 2-25 months) between the first and second sessions of PDT. CONCLUSION: Photodynamic therapy is a safe and effective treatment modality for choroidal nevus with subfoveal fluid. Photodynamic therapy provided satisfactory rates of resolution of subfoveal fluid in 87%, which was complete in 60% and partial in 27%. Further studies could further define the role and limitations of PDT for management of subfoveal fluid from choroidal nevus.