What question did this study set out to answer?

To determine whether dysregulated serum levels of IL-6, its soluble receptor complex, and TNF-α can serve as early prognostic biomarkers for disease severity in critical COVID-19 ARDS.

January 1, 2020Clinical and Medical InvestigationsOpen Access

Drastically elevated levels of Interleukin-6 and its soluble receptor complex in COVID-19 patients with acute respiratory distress

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Authors

GSGaetano Di SpignaUniversity of Naples Federico II DCDaniela Spalletti CerniaUniversity of Naples Federico II MVMaria VargasUniversity of Nevada, Las Vegas

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Implication

Observational study reveals elevated Interleukin-6 and depleted sgp130 in severe COVID-19 respiratory distress, suggesting cytokine receptor imbalance drives fatal hyper-inflammation.

Key Points

To determine whether dysregulated serum levels of IL-6, its soluble receptor complex, and TNF-α can serve as early prognostic biomarkers for disease severity in critical COVID-19 ARDS.
Evaluated N=23 critically ill patients with confirmed COVID-19 admitted to an intensive care unit with severe respiratory failure between March 10 and April 30.
Quantified serum concentrations of IL-6, sIL-6R, sgp130, and TNF-α using chemiluminescent immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA).
Serum IL-6 and TNF-α concentrations were significantly increased in critically ill COVID-19 patients across all stratified subgroups compared to controls.
Levels of the soluble antagonist receptor sgp130 were significantly decreased across all critical patients, while sIL-6R agonist levels showed variable elevation.

Cite This Study

Spigna et al. (2020) studied this question.

synapsesocial.com/papers/6a9e7f01b0981b863e2cc22e https://doi.org/10.15761/cmi.1000211

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Implication

Observational study reveals elevated Interleukin-6 and depleted sgp130 in severe COVID-19 respiratory distress, suggesting cytokine receptor imbalance drives fatal hyper-inflammation.

Drastically elevated levels of Interleukin-6 and its soluble receptor complex in COVID-19 patients with acute respiratory distress

Discussion

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Implication

Key Points

Cite This Study

Drastically elevated levels of Interleukin-6 and its soluble receptor complex in COVID-19 patients with acute respiratory distress

Discussion

Member takes

Implication

Key Points

Cite This Study

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