April 1, 2003AJP Renal Physiology

Male gender increases sensitivity to renal injury in response to cholesterol loading

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Why the study?

Does cholesterol loading cause more renal injury in male compared to female rats?

Population

Female and male rats

Comparison

Low-dose or high-dose cholesterol feeding for 24… vs No cholesterol feeding (control diet)

Design

Preclinical

Follow-up

24 weeks

Authors

DADiana M. AttiaMSD (Netherlands)RGRoel GoldschmedingUniversity Medical Center Utrecht MAMahmoud Attia

Discussion

Member takes

Implication

Rat model indicates greater male susceptibility to hypercholesterolemia-induced renal injury; leaves open human relevance and NOS mechanisms.

Structured PICO

Does cholesterol loading cause more renal injury in male compared to female rats?

Population

Female and male rats

Intervention

Low-dose or high-dose cholesterol feeding for 24 weeks

Comparator

No cholesterol feeding (control diet)

Outcome

Proteinuria, renal NOS activity, and renal injury (vascular, glomerular, and tubulointerstitial monocyte/macrophage influx)surrogate

Male rats are more sensitive to renal injury from hypercholesterolemia than female rats, potentially due to lower baseline renal nitric oxide synthase activity.

Cite This Study

Attia et al. (2003) studied this question.

synapsesocial.com/papers/6a9e7f11f7492f5efe95ea88 https://doi.org/10.1152/ajprenal.00009.2002

View Full Paper

Ask AI

Bookmark

Implication

Rat model indicates greater male susceptibility to hypercholesterolemia-induced renal injury; leaves open human relevance and NOS mechanisms.

Male gender increases sensitivity to renal injury in response to cholesterol loading

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Male gender increases sensitivity to renal injury in response to cholesterol loading

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider