The caging and photolytic release of alcohols has enormous potential for application in biological chemistry. A variety of stable 1-(2-nitrophenyl)-2,2,2-trifluoroethyl ether derivatives, which were readily prepared through Mitsunobu coupling reactions with an alcohol (ROH), underwent photolytic cleavage in high quantum yields (see scheme; R=alkyl, R′=H, OCH3).
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Specht et al. (2004) studied this question.
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