Prognostic value of lymphovascular invasion in Bismuth-Corlette type IV hilar cholangiocarcinoma

AIM: To assess the prognostic value of lymphovascular invasion (LVI) in Bismuth-Corlette type IV hilar cholangiocarcinoma (HC) patients. METHODS: A retrospective analysis was performed on 142 consecutively recruited type IV HC patients undergoing radical resection with at least 5 years of follow-up. Survival analysis was performed by the Kaplan-Meier method, and the association between the clinicopathologic variables and survival was evaluated by log-rank test. Multivariate analysis was adopted to identify the independent prognostic factors for overall survival (OS) and disease-free survival (DFS). Multiple logistic regression analysis was performed to determine the association between LVI and potential variables. CONCLUSION: LVI is associated with N1 stage and tumor size > 30 mm and adversely influences DFS and OS in type IV HC patients.