Answers are grounded in this paper and cite their sources.
Abstract:The hydroxylation of the tricyclic antidepressant drug, desmethylimipramine, has been studied by the use of isolated liver microsomes from human foetuses and adults. Desmethylimipramine was hydroxylated in both foetal and adult human liver microsomes. Thin‐layer chromatography of a chloroform extract of the incubate indicates that desmethylimipramine is aromatically hydroxylated in position 2.
No takes yet. Share an insight, caveat, or question.
Bahr et al. (1974) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: