Key result
Bovine rotavirus A was detected in 71% of diarrheic dairy calves in China, with G6P[1] being the predominant circulating genotype.
Why the study?
Data on the prevalence and molecular characteristics of bovine group A rotavirus (BoRVA) in dairy calves in China remained limited.
Cross-Sectional (n=269)
Yes
BoRVA circulates widely among young dairy calves in China, with G6P[1] being the predominant genotype, providing essential epidemiological data for future vaccine development.
Supports rotavirus surveillance in Chinese dairy herds; leaves open needs for genotype-matched vaccines and broader validation.
BACKGROUND: Bovine group A rotavirus (BoRVA) is a major cause of severe gastroenteritis in newborn dairy calves. Only one study has investigated the G and P genotypes among dairy calves in a few regions of China, which were G6 and P[5]. Therefore, data on the prevalence and molecular characteristics of BoRVA in dairy calves in China remains limited. OBJECTIVES: The purpose of this study was to investigate the prevalence and molecular characteristics of BoRVA in dairy calves in China. METHODS: 269 dairy calves diarrheic samples from 23 farms in six provinces in China were collected to detect BoRVA using reverse transcription polymerase chain reaction. RESULTS: 71% of samples were determined to be BoRVA-positive. Two G genotypes (G6, G10) and two P genotypes (P[1], P[5]) were identified, and G6P[1] BoRVA was the predominant strain. Moreover, the VP7 and VP4 gene sequences of these dairy calf BoRVA strains revealed abundant genetic diversity. Interestingly, eight out of 17 complete G6 VP7 sequences were clustered into G6 lineage VI and analysis showed the strains were closely related to Chinese yak BoRVA strains. CONCLUSIONS: The results of this study show that BoRVA circulates widely among dairy calves in China, and the dominant genotype in circulation is G6P[1], first report on molecular characteristics of complete P[5] VP4 genes in chinese dairy calves. These results will help us to further understand the prevalence and genetic evolution of BoRVA among dairy calves in China and, thus, prevent the disease more effectively.
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Liu et al. (2021) conducted a cross-sectional in Diarrhea (Bovine rotavirus A infection) (n=269). Bovine rotavirus A infection was evaluated on Prevalence of Bovine rotavirus A. Bovine rotavirus A was detected in 71% of diarrheic dairy calves in China, with G6P[1] being the predominant circulating genotype.
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