Key result
Statin treatment in patients with abdominal aortic aneurysm was associated with higher APC-PCI complex (P=0.034) and lower homocysteine levels (P=0.021).
Why the study?
Does statin treatment improve markers of inflammation, vasoconstriction, and coagulation in patients with abdominal aortic aneurysm?
Observational (n=325)
Does statin treatment improve markers of inflammation, vasoconstriction, and coagulation in patients with abdominal aortic aneurysm?
Statin treatment in patients with abdominal aortic aneurysm is associated with higher APC-PCI complex and lower homocysteine levels, suggesting potential beneficial effects on coagulation and vasoconstriction.
Answers are grounded in this paper and cite their sources.
May indicate favorable coagulation effects in AAA; leaves open impact on clinical outcomes.
The association of statins with markers of inflammation, vasoconstriction, and coagulation was evaluated in 325 patients with abdominal aortic aneurysm with respect to statin treatment or not. Variables evaluated included routine laboratory markers, lipids, homocysteine, endothelin-1, matrix metalloproteinases (MMP)-2 and -9, and activated protein C-protein C inhibitor (APC-PCI) complex. Statin-treated patients were more often male (85% vs 75%; P = .024) and had ischemic heart disease (57% vs 19%; P < .0001). They showed lower levels of cholesterol (P < .0001), homocysteine (P = .027), MMP-9 (P = .038), and endothelin-1 (P = .005), and higher levels of APC-PCI complex (P = .042). Differences persisted in logistic regression for cholesterol (P < .0001), APC-PCI complex (P = .034), and homocysteine (P = .021). Statin-treated patients with abdominal aortic aneurysm show higher APC-PCI complex and lower homocysteine levels. Whether this translates into lower risk for aneurysm expansion or rupture will be evident from further follow-up.
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Gottsäter et al. (2008) conducted an observational in abdominal aortic aneurysm (n=325). Statin treatment vs. No statin treatment was evaluated on Markers of inflammation, vasoconstriction, and coagulation (including cholesterol, APC-PCI complex, and homocysteine) (p=<.0001 for cholesterol, .034 for APC-PCI, .021 for homocysteine). Statin treatment in patients with abdominal aortic aneurysm was associated with higher APC-PCI complex (P=0.034) and lower homocysteine levels (P=0.021).
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