NPB-1575 improves ischemic brain injury by regulating microglial polarization via IRS2 signaling pathway

Q: What does this research mean for the field?

The novel neuroprotectant NPB-1575 alleviates cerebral ischemic injury and inhibits neuroinflammation by switching microglial polarization from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype via the IRS2/Nrf2/NF-κB signaling pathway. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Meng-Yao Liu; Xin-Nan Li; Nian-ying Shang; Liwen Zhang; Songyang Sui; An-Hua Tao; Jingshu Tang; Lei Wu; Jungui Dai; Ying Peng

doi:10.1080/10286020.2026.2726155

September 4, 2026Journal of Asian Natural Products Research

NPB-1575 improves ischemic brain injury by regulating microglial polarization via IRS2 signaling pathway

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Key Points

To determine whether the neuroprotectant NPB-1575 mitigates ischemic stroke injury by modulating microglial polarization and neuroinflammatory signaling.
Evaluated the therapeutic activity of the novel neuroprotective agent NPB-1575 in models of cerebral ischemic injury.
Assessed microglial phenotypic switching between pro-inflammatory M1 and anti-inflammatory M2 states alongside changes in the IRS2/Nrf2/NF-κB signaling axis.
NPB-1575 administration reduced neuroinflammation and attenuated overall cerebral ischemic injury.
NPB-1575 prompted a microglial phenotypic switch from the pro-inflammatory M1 state to the anti-inflammatory M2 state through activation of the IRS2/Nrf2/NF-κB signaling pathway.

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Implication

Preclinical investigation reveals NPB-1575 reduces brain injury by shifting microglia to an anti-inflammatory state, suggesting a therapeutic role for stroke.

Abstract

Modulating microglial polarization is a promising ischemic stroke therapeutic strategy. This study confirms that the novel neuroprotectant NPB-1575 inhibits neuroinflammation and alleviates cerebral ischemic injury. It switches microglial polarization from pro-inflammatory M1 to anti-inflammatory M2 via the IRS2/Nrf2/NF-κB signaling pathway.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a9e8559c3034f961570d7f7 https://doi.org/10.1080/10286020.2026.2726155

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NPB-1575 improves ischemic brain injury by regulating microglial polarization via IRS2 signaling pathway

Key Points

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Implication

Abstract

Discussion

Cite This Study

NPB-1575 improves ischemic brain injury by regulating microglial polarization via IRS2 signaling pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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