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September 7, 2026Current Neuropharmacology

The Dorsal Raphe Nucleus: A Critical Hub in the Neurocircuitry of General Anesthesia

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Authors

AWAnyin WangHZHui ZhouXWXinghe Wang

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Overview

Review reveals dorsal raphe nucleus circuits control anesthetic depth and emergence in surgical patients, indicating promising targets for personalized perioperative care.

Key Points

  • To synthesize current evidence on how distinct neuronal subpopulations in the dorsal raphe nucleus regulate general anesthesia induction and emergence.
  • Narrative review synthesizing preclinical and clinical studies examining neurocircuit mechanisms underlying anesthetic action.
  • Analyzed functional interactions among dorsal raphe serotonergic, GABAergic, glutamatergic, and dopaminergic cell populations during anesthesia.
  • Serotonergic neurons promote cortical arousal to accelerate anesthetic emergence, whereas local GABAergic neurons mediate hypnosis by suppressing serotonergic tone.
  • Glutamatergic neurons demonstrate resistance to anesthetic suppression, while dopaminergic neurons encode salience and modulate perioperative pain perception.
  • Functional heterogeneity within raphe neurocircuits provides a mechanistic basis for atypical anesthetic sensitivity observed in patients with anxiety and depression.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a9e858ac3034f961570db56https://doi.org/10.2174/011570159x490032260630163835
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dorsal raphe nucleus to basolateral amygdala 5-HTergic neural circuit modulates restoration of consciousness during sevoflurane anesthesia2024 · 5 citations
  2. 2DMH glutamatergic and GABAergic neurons differentially regulate post-anesthesia sleep disturbance through CB1R signaling2026
  3. 3Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance2026
  4. 4Restoring the loss of consciousness under sevoflurane anesthesia in states of anxiety and depression by potently activating serotonergic pathways in brain2024
  5. 5DORSAL RAPHE NUCLEUS CONTROLS MOTIVATIONAL STATE TRANSITIONS IN MONKEYS2024 · 10 citations