Survival outcome of Gallbladder cancer in the US: An updated surveillance, epidemiology, and end results-based analysis of age and gender disparities

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Male gender, older age, and distant tumor stage are significant predictors of higher mortality in gallbladder cancer, while chemotherapy and surgery substantially improve survival. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ayrton Bangolo; Behzad Amoozgar; Budoor Alqinai; Ravleen Chowdhary; Rishabh Goyal

doi:10.55729/2000-9666.1601

September 4, 2026Journal of Community Hospital Internal Medicine PerspectivesOpen Access

Survival outcome of Gallbladder cancer in the US: An updated surveillance, epidemiology, and end results-based analysis of age and gender disparities

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Key Points

To evaluate the impact of gender, age, tumor stage, and treatment modalities on overall and cancer-related mortality among patients with gallbladder cancer.
Retrospective analysis of 1,527 patients diagnosed with gallbladder cancer between 2005 and 2021 using SEER registry data.
Assessed demographic factors, tumor stage, and interventions including surgery, chemotherapy, and radiation.
Multivariate Cox proportional hazards regression models were used to estimate hazard ratios (HRs) for mortality while adjusting for confounders.
The cohort (N=1,527) was predominantly female (68.11%), with 56.65% diagnosed between ages 60 and 79 years, and 65.49% presenting with regional-stage disease.
Multivariate analysis showed male gender was significantly associated with increased overall mortality risk (HR=1.19, 95% CI 1.05-1.36).
Older age and distant-stage disease predicted higher mortality, whereas surgical resection and chemotherapy significantly improved survival outcomes.

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Implication

Retrospective cohort study reveals higher mortality in male and older gallbladder cancer patients, highlighting the need for tailored interventions.

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Bangolo et al. (2026) studied this question.

synapsesocial.com/papers/6a9e85c4c3034f961570e125 https://doi.org/10.55729/2000-9666.1601

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Survival outcome of Gallbladder cancer in the US: An updated surveillance, epidemiology, and end results-based analysis of age and gender disparities

Key Points

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Discussion

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Survival outcome of Gallbladder cancer in the US: An updated surveillance, epidemiology, and end results-based analysis of age and gender disparities

Key Points

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