Chicks on artificial diets containing 0.5% cholesterol and 10% corn oil were further supplemented with thyroid powder or propylthiouracil at 2 different dosage levels. Liver and plasma lipids were fractionated into class groups by silicic acid column chromatography. Sterol ester and phospholipid fatty acids were analyzed for percentage composition by alkaline isomerization and ultraviolet spectrophotometry. Thyroid powder inhibited the specific accumulation of liver cholesteryl monoenoate that follows dietary supplementation with oil and cholesterol. It also reduced plasma concentrations of individual fatty acids. Thiouracil increased all plasma lipid components but did not increase hepatic total lipid. The per cent of liver and plasma phospholipid dienoic acid was reduced by thyroid and increased by thiouracil, suggesting that thyroidal activity may be related to biological transformation of dienoic acid.
No takes yet. Share an insight, caveat, or question.
Evans et al. (1962) studied this question.