Two cases of holoacardius are presented. Both had a normal 46,XX female karyotype, identical to that of their respective cotwin. Data are presented supporting the concept that the placental vascular anastomoses are the primary agents in the formation of an acardiac. Cytogenetics, epidemiology and other theories of pathogenesis are discussed.
No takes yet. Share an insight, caveat, or question.
Kaplan et al. (1979) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: