Key result
Sedation with Amytal decreased cardiac output and increased peripheral resistance, invalidating its theoretic basis for selecting hypertensive patients for sympathectomy.
Why the study?
Does amobarbital sedation alter cardiac output and peripheral resistance in normal and hypertensive men?
Does amobarbital sedation alter cardiac output and peripheral resistance in normal and hypertensive men?
Amobarbital sedation decreases cardiac output and increases peripheral resistance, invalidating its theoretic use as a device for selecting hypertensive patients for sympathectomy.
Answers are grounded in this paper and cite their sources.
Challenges Amytal use for sympathectomy selection; leaves open need for validated predictive tests.
Measurements of cardiac output and intra-arterial pressure on 5 normal young men and 5 hypertensive patients before and during sedation with Amytal demonstrated a decreased cardiac output and an increased peripheral resistance during the period of sedation. It is concluded that the theoretic basis for the use of Amytal sedation as a device for selection of hypertensive patients for sympathectomy is not valid.
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Winchell et al. (1951) studied Hypertension (n=10). Amytal vs. Before sedation (baseline) was evaluated on Cardiac output and peripheral resistance. Sedation with Amytal decreased cardiac output and increased peripheral resistance, invalidating its theoretic basis for selecting hypertensive patients for sympathectomy.
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