The Effect of Halothane

Design: Comparative study Setting: In CMH, Kharian and NishtarHospital, Multan. Period: From April 2003 to March 2004. Material & Methods: We studied 100 patients aged 18-45years undergoing elective surgery. We compared the effects of halothane in two groups, one premedicated and otherunpremedicated on the variability in the blood pressure. Group-I was premedicated with diazepam 5 mg orally andmidazolam 7.5 mg orally, aged between 18-45 years undergoing elective surgery. The blood pressure was monitorednon-invasively in the ward, in the operation theatre during induction and when halothane is switched on. These groupsof patients did not show any significant haemodynamic changes. The blood pressure remained within the normal limits.The second group of fifty patients underwent elective surgery, but they were not given any above mentioned premedication,they also belong to same age group. They showed significant haemodynamic changes i.e. rise in bloodpressure and beat to beat heart rate variability. This variability was caused by fluctuating balance of sympathetic andparasympathetic tone at the sino-artrial node. Statistical analysis was carried out using student “t” test. Differences wereconsidered significant when P > 0.05 & all values were presented 95 mean (SEM).