What question did this study set out to answer?

To determine whether leptin alters behavioral responsiveness to sweet tastants directly through functional Ob-Rb leptin receptors expressed in peripheral taste cells.

November 3, 2003EndocrinologyOpen Access

Leptin Modulates Behavioral Responses to Sweet Substances by Influencing Peripheral Taste Structures

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Authors

NSNoriatsu ShigemuraKyushu University RORie OhtaKyushu University YKYuko KusakabeNational Agriculture and Food Research Organization

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Implication

Animal experiment demonstrates that leptin suppresses sweet taste preferences through peripheral Ob-Rb receptors in mice, indicating direct hormonal regulation of taste in feeding behavior.

Key Points

To determine whether leptin alters behavioral responsiveness to sweet tastants directly through functional Ob-Rb leptin receptors expressed in peripheral taste cells.
Assessed Ob-Rb mRNA expression and sequence integrity in taste cells of lean, leptin-deficient (ob/ob), and leptin-receptor-deficient (db/db) mice using RT-PCR and in situ hybridization.
Measured behavioral taste responses to sucrose and saccharin following intraperitoneal leptin administration using sweet-bitter mixture tests and a conditioned taste aversion paradigm.
Normal Ob-Rb mRNA expression was confirmed in taste cells of lean and ob/ob mice, whereas db/db mice expressed an abnormal transcript with a defective, truncated intracellular signaling domain.
Intraperitoneal leptin injection significantly diminished behavioral preferences for sucrose and saccharin in lean and ob/ob mice, while db/db mice displayed no suppression in sweet taste responses.

Cite This Study

Shigemura et al. (2003) studied this question.

synapsesocial.com/papers/6a9e8a32c139645e08f0c216 https://doi.org/10.1210/en.2003-0602

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Implication

Animal experiment demonstrates that leptin suppresses sweet taste preferences through peripheral Ob-Rb receptors in mice, indicating direct hormonal regulation of taste in feeding behavior.

Leptin Modulates Behavioral Responses to Sweet Substances by Influencing Peripheral Taste Structures

Discussion

Member takes

Implication

Key Points

Cite This Study

Leptin Modulates Behavioral Responses to Sweet Substances by Influencing Peripheral Taste Structures

Discussion

Member takes

Implication

Key Points

Cite This Study

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