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September 1, 2006Seminars in Thrombosis and Hemostasis

Comparative Analysis and Classification of von Willebrand Factor/Factor VIII Concentrates: Impact on Treatment of Patients with von Willebrand Disease

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Key result

Among 12 vWF/FVIII concentrates, Haemate P/Humate-P had the highest content of HMWvWF multimers, specific vWF activities, and vWF:RCo and vWF:CB per unit of FVIII:C.

Population

12 commercially available vWF/FVIII concentrates

Design

Preclinical

Authors

UBUlrich BuddeAsklepios Klinik AltonaHMHubert MetznerBehringwerke (Germany)HMH MüllerBehringwerke (Germany)

Discussion

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Implication

May guide vWF concentrate selection in vWD; animal data leave open translation to human bleeding outcomes.

Structured PICO

P
Population
12 commercially available vWF/FVIII concentrates
E
Exposure
Comparative analysis of biochemical properties
O
Outcome
Content and activities of FVIII and vWF, and content of high molecular weight vWF (HMWvWF) multimerssurrogate

Commercially available vWF/FVIII concentrates differ substantially in their biochemical properties, with Haemate P/Humate-P showing the highest content of functionally active high molecular weight vWF multimers.

Cite This Study

Budde et al. (2006) studied von Willebrand disease. vWF/FVIII concentrates was evaluated on Content and activities of FVIII and vWF, and content of HMWvWF multimers. Among 12 vWF/FVIII concentrates, Haemate P/Humate-P had the highest content of HMWvWF multimers, specific vWF activities, and vWF:RCo and vWF:CB per unit of FVIII:C.

synapsesocial.com/papers/6a9e8a73185d8243f937fff2https://doi.org/10.1055/s-2006-949668
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Von Willebrand factor/factor VIII concentrates in the treatment of von Willebrand disease2009 · 40 citations
  2. 2In vitro Evaluation of a Very‐High‐Purity, Solvent/Detergent‐Treated, Von Willebrand Factor Concentrate1991 · 23 citations
  3. 3Biological effects of a S/D-treated, very high purity, von Willebrand factor concentrate in five patients with severe von Willebrand disease1993 · 20 citations
  4. 4Optimizing therapy with factor VIII/von Willebrand factor concentrates in von Willebrand disease1998 · 36 citations
  5. 5Use of ristocetin cofactor activity in the management of von Willebrand disease2001 · 14 citations