Biomarkers of Renal and Overall Survival in Patients with Granulomatosis Polyangiitis

Granulomatosis with polyangiitis (GPA) is a kind of small blood vessel vasculitis that is characterized by lung and renal involvement with a high mortality rate. This study was aimed to investigate the association of baseline laboratory, demographic, clinical parameters between renal and overall survival in patients with GPA. Methods: Twenty-four patients diagnosed with GPA between 2010 and 2020 from a tertiary hospital were analyzed retrospectively. Baseline hematological and biochemical parameters, C reactive protein (CRP), and antineutrophil cytoplasmic antibodies (ANCA) were also recorded. History of plasmapheresis and acute dialysis were recorded. Primary endpoints were defined as the diagnosis of end-stage kidney disease and mortality. Results: Mean age of patients were 53,0013,78. Ten (41,7%) of 24 patients were male. Median estimated glomerular filtration (eGFR) rate was 62 ml/min/1,73m2 (22,50-88,75).C-ANCA was positive in 15 (65%) patients. Median proteinuria level was 1,30 gr/day (0,80-2,05). Median CRP level was 14,00 g/dl at baseline Cox regression analysis with the adjusted model by age and gender showed that platelet count, eGFR, proteinuria, and CRP levels were significantly associated with renal survival and hemoglobin levels were also associated with overall survival. Platelet count below 150 103/L and hemoglobin levels below 12 g/dL showed the worst prognosis in terms of renal and overall survival.