Key result
Elevated inspiratory work loads for 4.5 minutes increased cardiac output by an average of 1.84 L/min and O2 consumption by 108 ml/min.
Why the study?
Does elevated inspiratory work load increase cardiac output and O2 consumption in human subjects?
Population
9 human subjects (5 in the main study, 4 in a separate series of experiments)
Comparison
Elevated inspiratory work loads using an… vs Rest without added respiratory loads
Design
Other
Follow-up
4.5 min
Authors
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May raise cardiac output via metabolic demand in acute loading; leaves open translation to chronic cardiopulmonary disease.
Does elevated inspiratory work load increase cardiac output and O2 consumption in human subjects?
Elevated inspiratory work loads increase cardiac output as a metabolic effect of increased work load rather than primarily due to negative intrathoracic pressure.
Coast et al. (1988) studied this question. Elevated inspiratory work loads vs. Rest without added respiratory loads was evaluated on Cardiac output and O2 consumption. Elevated inspiratory work loads for 4.5 minutes increased cardiac output by an average of 1.84 L/min and O2 consumption by 108 ml/min.