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Will optical resolution by HPLC with chiral columns become obsolete? With a new technique, which should be amenable to upscaling, suspensions of crystalline host compounds such as 1 and 2 in hexane or water form 1:1 complexes with the one enantiomer of a racemic alcohol or ether such as 3 and 4 that fits best into its lattice. The two enantiomers can then be separated by vacuum distillation.
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Gerd Kaupp (1994) studied this question.
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