Discordance in LVEF Between Nuclear SPECT and Echocardiography in Patients With Moderate Reduction in LVEF

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Heart failure (n=235). Intervention: Echocardiography (ECHO) vs. Single-photon emission computed tomography (SPECT). Primary outcome: Correlation of LVEF between ECHO and SPECT (r = 0.76, p=≤0.05).

Muhammad Shabbir Rawala; Adil Memon; Muhammad Yasin; Vallabh Karpe; Zachary S. Brewer; Cecilia V. Harrington; Suzanne Kemper; William H. Carter

doi:10.1177/8756479319828378

February 13, 2019Journal of diagnostic medical sonography

Discordance in LVEF Between Nuclear SPECT and Echocardiography in Patients With Moderate Reduction in LVEF

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Key result

Echocardiography and SPECT showed a moderately positive correlation for LVEF overall (r=0.76, P≤0.05), but a weak correlation in patients with LVEF of 25% to 50% (r=0.43, P≤0.05).

Why the study?

LVEF is vital to manage heart failure, but studies have reported variable correlations for LVEF between echocardiography and SPECT.

Does echocardiography correlate with SPECT for measuring LVEF in patients?

Study Design

Type

Observational (n=235)

Structured PICO

Does echocardiography correlate with SPECT for measuring LVEF in patients?

P

Population

235 patients who underwent LVEF assessment via both echocardiography and SPECT within 72 hours.

E

Exposure

Echocardiography (ECHO)

C

Comparator

Single-photon emission computed tomography (SPECT)

O

Outcome

Correlation of Left Ventricular Ejection Fraction (LVEF) measurements between ECHO and SPECTsurrogate

Main Result

Effect estimate: r = 0.76

Absolute Event Rate: 51% vs 57%

p-value: p=≤0.05

LVEF measurements between ECHO and SPECT show only weak correlation in patients with moderately reduced LVEF (25-50%), suggesting further imaging may be needed when making device or medication decisions.

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Implication

May warrant caution using echo or SPECT interchangeably for LVEF in moderate range; leaves open need for validation trials.

Abstract

Left ventricular ejection fraction (LVEF) is vital to manage heart failure (HF). Studies have reported variable correlations for LVEF between echocardiography (ECHO) and single-photon emission computed tomography (SPECT). A retrospective review of 235 patients was conducted to compare LVEF via ECHO and SPECT done within 72 hours. Mean LVEF by ECHO was 51% and 57% by SPECT. A moderately positive correlation resulted ( r = .76, P ≤ .05) for all, but a weak correlation was noted in 99 with LVEF of 25% to 50% ( r = .43, p≤0.05). Further imaging may be needed for discordant results when medications and/or devices are considered.

Discussion

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Cite This Study

Rawala et al. (2019) conducted an observational in Heart failure (n=235). Echocardiography (ECHO) vs. Single-photon emission computed tomography (SPECT) was evaluated on Correlation of LVEF between ECHO and SPECT (r = 0.76, p=≤0.05). Echocardiography and SPECT showed a moderately positive correlation for LVEF overall (r=0.76, P≤0.05), but a weak correlation in patients with LVEF of 25% to 50% (r=0.43, P≤0.05).

synapsesocial.com/papers/6a9e8dfd17da107d9cbe63e4 https://doi.org/10.1177/8756479319828378

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Discordance in LVEF Between Nuclear SPECT and Echocardiography in Patients With Moderate Reduction in LVEF

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Discordance in LVEF Between Nuclear SPECT and Echocardiography in Patients With Moderate Reduction in LVEF

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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