Key result
Gated SPECT and ERNV showed high correlation for estimating left ventricular ejection fraction (R2 = 0.93), but gated SPECT and echocardiography had poor correlation for wall thickening (kappa=0.31).
Why the study?
Do gated SPECT and anatomical M-mode echocardiography agree with equilibrium radionuclide ventriculography in evaluating LVEF, wall thickening, and wall motion in patients with suspected ischaemic heart disease?
Observational (n=16)
Do gated SPECT and anatomical M-mode echocardiography agree with equilibrium radionuclide ventriculography in evaluating LVEF, wall thickening, and wall motion in patients with suspected ischaemic heart disease?
Effect estimate: R2 = 0.93 (LVEF ERNV vs GSPECT)
p-value: p=< 0.05
While LVEF estimations by GSPECT, echocardiography, and ERNV agree sufficiently for clinical practice, wall thickening estimates from echocardiography and GSPECT cannot be used interchangeably.
Gated SPECT LVEF may align with ERNV in suspected IHD; leaves open whether wall thickening estimates are interchangeable with echocardiography.
Left ventricular ejection fraction (LVEF) and wall thickening are fundamental aspects of cardiac function. Recently, gated single photon emission computerised tomography (GSPECT) and anatomical M-mode echocardiography are new techniques, which have been introduced for the evaluation of left ventricular wall thickening and ejection fraction. These, however, have not been evaluated against established techniques, including equilibrium radionuclide ventriculography (ERNV), which remains the current gold standard for the evaluation of LVEF. We examined the concordance between LVEF, wall motion and wall thickening scores derived from GSPECT, echocardiography and ERNV, in a group of 16 patients with suspected ischaemic heart disease. Estimated ejection fraction correlated better between ERNV and gated SPECT (R2 = 0.93) than between echocardiography and either gated SPECT (R2 = 0.62) or ERNV (R2 = 0.71). There was poor correlation between gated SPECT and anatomical M-mode echocardiography in the assessment of wall thickening (83/150, 56%; kappa= 0.31, p < 0.05) and similar correlation (100/150, 66%; kappa = 0.29, p < 0.01) for wall motion analysis. In conclusion, estimations of ejection fraction by all the three studied modalities agreed to a degree sufficient for routine clinical practice. However, estimates of wall thickening from echocardiography cannot be used interchangeably with those derived from gated myocardial perfusion SPECT.
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Mohan et al. (2004) conducted an observational in Suspected ischaemic heart disease (n=16). Gated single photon emission computerised tomography (GSPECT) and anatomical M-mode echocardiography vs. Equilibrium radionuclide ventriculography (ERNV) was evaluated on Concordance between LVEF, wall motion and wall thickening scores (R2 = 0.93 (LVEF ERNV vs GSPECT), p=< 0.05). Gated SPECT and ERNV showed high correlation for estimating left ventricular ejection fraction (R2 = 0.93), but gated SPECT and echocardiography had poor correlation for wall thickening (kappa=0.31).
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