Key result
New positive inotropic agents with mixed vasodilator properties are not true digitalis replacements, and the ideal drug and patient population for inotropic therapy in CHF remain unidentified.
Population
Patients with congestive heart failure (CHF)
Comparison
New cardiotonic drugs vs Digitalis
Design
Review
Authors
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Caution against using mixed inotropic-vasodilators as digitalis replacements in CHF; leaves open identification of ideal drug and population.
The search for a pure cardiotonic replacement for digitalis remains unfulfilled, as new agents possess mixed inotropic-vasodilator properties and are difficult to evaluate in late-stage CHF.
Paul Erhardt (1987) conducted a review in Congestive Heart Failure (CHF). New CT drugs (positive inotropic agents) vs. Digitalis was evaluated. New positive inotropic agents with mixed vasodilator properties are not true digitalis replacements, and the ideal drug and patient population for inotropic therapy in CHF remain unidentified.
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