Key result
Biological therapies for breast cancer carry a risk of cardiotoxicity, though mechanisms and management strategies remain incompletely defined.
Why the study?
Do biological therapies cause cardiovascular complications in breast cancer patients?
Do biological therapies cause cardiovascular complications in breast cancer patients?
Biological therapies for breast cancer are associated with a risk of cardiotoxicity, highlighting the importance of cardiovascular monitoring in this growing survivor population.
May warrant monitoring in breast cancer patients on biologics; leaves mechanisms and management strategies open for prospective study.
BACKGROUND: With increasing number of breast cancer survivors, treatment-associated toxicities are gaining importance because they may decrease quality of life and shorten expected survival. Biological treatment strategies are less toxic than conventional chemotherapy. However, practically all biological therapies for breast cancer induce cardiovascular complications. In the case of targeted therapies mechanisms of cardiotoxicity and strategies to manage cardiovascular disorders have not been completely defined. METHODS: Articles were found by searching PubMed and abstract databases of several oncological meetings. This review summarizes the risks and mechanisms of cardiovascular complications associated with biological agents used in treatment of breast cancer. RESULTS/CONCLUSION: Introduction of biological therapies has resulted in reduction of morbidity and mortality of breast cancer patients in recent years. However, all biological strategies bring a risk of cardiotoxicity and despite progress in the knowledge and management of cardiovascular complications there are still many unaswered questions.
No takes yet. Share an insight, caveat, or question.
Wysocki et al. (2008) conducted a review in Breast cancer. Biological therapies was evaluated on Cardiovascular complications. Biological therapies for breast cancer carry a risk of cardiotoxicity, though mechanisms and management strategies remain incompletely defined.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: