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June 1, 2022Current Cardiology Reviews

Cardiotoxicity of Biological Therapies in Cancer Patients: An In-depthReview

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Why the study?

Understanding of the cardiac side effects of biological therapies is rapidly evolving, and cardiotoxicity is becoming increasingly significant as cancer patients achieve higher life expectancy with targeted agents.

What are the cardiovascular toxicities associated with novel biological therapies in cancer patients, and what are the strategies for their diagnosis and management?

Design

Review

Authors

LMLuai MadanatCorewell HealthRGRuby GuptaPWPaul Weber

Discussion

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Implication

Cardiotoxicity vigilance is warranted with novel biologics in longer-surviving patients; leaves open prospective risk-stratification studies.

Structured PICO

What are the cardiovascular toxicities associated with novel biological therapies in cancer patients, and what are the strategies for their diagnosis and management?

P
Population
Cancer patients receiving biological therapies
I
Intervention
Novel biological therapies including anti-HER2 antibodies, tyrosine kinase inhibitors, bruton kinase inhibitors, antivascular endothelial growth factors, proteasome inhibitors, immunomodulator drugs, and immune checkpoint inhibitors
O
Outcome
Cardiovascular toxicities (hypertension, arrhythmias, QT prolongation, myocardial ischemia and infarction, left ventricular dysfunction, congestive heart failure, and thromboembolism)safety

This review provides a comprehensive overview of the cardiotoxic effects of novel biological therapies in cancer patients, emphasizing the importance of early detection and timely intervention.

Cite This Study

Madanat et al. (2022) studied this question.

synapsesocial.com/papers/6a7039b178a11c550e0a12dbhttps://doi.org/10.2174/1573403x18666220531094800

Topics

Cardio-oncology
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