Key result
Vaccination with a 6 PD50 potency foot-and-mouth disease vaccine, particularly when followed by a booster dose, elicited significantly higher neutralizing antibody titers compared to a single 3 PD50 dose in calves with maternal antibodies.
Why the study?
Does high potency FMD vaccine (6 PD50) with or without booster improve neutralizing antibody titers in calves with maternal antibodies?
RCT (n=111)
Randomly assigned to four groups
No
Does high potency FMD vaccine (6 PD50) with or without booster improve neutralizing antibody titers in calves with maternal antibodies?
p-value: p=<0.05
In calves with maternal antibodies, a high-potency (6 PD50) FMD vaccine with a booster dose is required to overcome maternal interference and provide continuous protection.
High-potency FMD vaccines with boosters may overcome maternal antibody interference in calves; leaves open optimal field regimens pending larger trials.
Foot-and-mouth disease is one of the most important viral diseases of cloven-hoofed animals.Mass vaccination is an effective method to control the disease and is frequently utilized in endemic regions.Sufficient protection of young animals is important in mass vaccination campaigns.Maternal antibodies negatively affect the success of vaccination.Hence, determination of the optimal vaccination age is crucial for the uninterrupted protection of young animals.This study was performed to identify the effect of vaccine potency and booster administration on serum neutralizing antibody titers of calves with different levels of maternal antibodies.Calves (n = 111) on a state farm were used in this study.Oil adjuvant foot-and-mouth disease vaccines with 3 PD50 and 6 PD50 potencies were used with or without booster administration.Serum samples were collected each month up to day 120 postvaccination.Virus neutralization tests were used to measure the serum neutralizing antibody titers and estimate the protection period by using pre-determined cut-off values for protection.The results revealed that a vaccination with a 6 PD50 potency vaccine, preferably followed by a booster dose, should be used to overcome maternal immunity for incessant protection.
No takes yet. Share an insight, caveat, or question.
Çokçalışkan et al. (2017) conducted an RCT in Foot-and-mouth disease maternal antibody interference (n=111). 6 PD50 potency foot-and-mouth disease vaccine vs. 3 PD50 potency foot-and-mouth disease vaccine or unvaccinated was evaluated on Serum neutralizing antibody titers at day 60 postvaccination (p=<0.05). Vaccination with a 6 PD50 potency foot-and-mouth disease vaccine, particularly when followed by a booster dose, elicited significantly higher neutralizing antibody titers compared to a single 3 PD50 dose in calves with maternal antibodies.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: