Key result
Dynamic light scattering (DLS) assessment of red blood cell movement during stasis showed that the RBC diffusion coefficient correlates with biological age and coagulation factors.
A novel non-invasive dynamic light scattering method can assess hemostasis and vascular function by measuring RBC movement during induced stasis.
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Hypothesis-generating for non-invasive hemostasis assessment; prospective validation required before clinical adoption.
We present a new non-invasive method for assessing hemostasis in vivo. This method is based on the analysis of the movement characteristics of red blood cells (RBCs) during blood stasis condition. Stasis is intermittently induced by occlusion of arterial blood flow at the finger root. We assumed that under zero flow conditions, RBC movement is driven mostly by Brownian motion, and we characterized the RBC movement by utilizing the dynamic light scattering (DLS) technique in vivo. We found that during the stasis the RBCs diffusion coefficient in plasma decreases. We speculate that the RBC diffusion coefficient is most strongly related to endothelial and hemostatic activity. This assumption is supported by our findings that RBC movement, being expressed through the characteristics of the measured DLS signal, is correlative to the biological age and also is related to the coagulation factors. This new method can serve as a new diagnostic and research tool for the assessment of hemostasis and vascular function.
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Fine et al. (2011) studied this question. Dynamic light scattering (DLS) was evaluated on Red blood cell (RBC) diffusion coefficient during stasis. Dynamic light scattering (DLS) assessment of red blood cell movement during stasis showed that the RBC diffusion coefficient correlates with biological age and coagulation factors.
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