Key result
High-level MYC amplification and epithelioid cell morphology were observed in 2 cases of cutaneous angiosarcoma arising in massive chronic lymphedema of morbid obesity.
Case Report (n=2)
MYC amplification can be present in cutaneous angiosarcoma secondary to massive chronic lymphedema of morbid obesity.
Supports MYC amplification in obesity-related lymphedema angiosarcoma; leaves open diagnostic utility pending larger validation.
BACKGROUND: Angiosarcoma is a malignancy of vascular endothelial cells which may arise secondarily as a complication of lymphedema, including chronic lymphedema of morbid obesity. Amplifications in MYC are frequently present in secondary angiosarcoma (arising in irradiated sites and chronic lymphedema) and less frequently in primary cutaneous angiosarcoma. OBJECTIVE: To describe the presence of MYC amplifications in two cases of cutaneous angiosarcoma secondary to chronic lymphedema of morbid obesity. METHODS: This study is a case series of two patients with cutaneous angiosarcoma. Clinical data was retrieved from the medical records. Histopathological analysis of the biopsy specimens was performed, including immunohistochemistry, along with fluorescence in situ hybridization. RESULTS: Angiosarcoma arose in the setting of massive chronic lymphedema complicating morbid obesity without other predisposing risk factors. Both cases exhibited epithelioid cell morphology and high-level MYC amplification. CONCLUSION: We report MYC amplification in two cases of angiosarcoma arising in massive chronic lymphedema of morbid obesity.
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Harker et al. (2016) conducted a case report in Cutaneous angiosarcoma secondary to chronic lymphedema of morbid obesity (n=2). Massive chronic lymphedema of morbid obesity was evaluated on Presence of MYC amplifications and epithelioid cell morphology. High-level MYC amplification and epithelioid cell morphology were observed in 2 cases of cutaneous angiosarcoma arising in massive chronic lymphedema of morbid obesity.
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